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J Microbiol Immunol Infect ; 54(1): 27-36, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-813694

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative viral pathogen of coronavirus disease 2019 (COVID-19), appears to have various clinical presentations and may result in severe respiratory failure. The global SARS-CoV-2-associated viral pneumonia pandemic was first reported in December 2019 in China. Based on known pharmacological mechanisms, many therapeutic drugs have been repurposed to target SARS-CoV-2. Among these drugs, remdesivir appears to be the currently most promising according to several clinical trials and reports of compassionate use. In this mini-review, we summarize the current evidence on the efficacy and challenges of remdesivir for the treatment of coronavirus disease 2019 (COVID-19).


Subject(s)
Adenosine Monophosphate/analogs & derivatives , Alanine/analogs & derivatives , Antiviral Agents/administration & dosage , COVID-19 Drug Treatment , Adenosine Monophosphate/administration & dosage , Alanine/administration & dosage , COVID-19/epidemiology , China/epidemiology , Clinical Trials as Topic , Humans , Pandemics , Randomized Controlled Trials as Topic , SARS-CoV-2/drug effects
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